Work

Treatment targets of cellular senescence and circadian rhythms in ischemic stroke

Year: 2025

Type: article

Abstract: Ischemic stroke poses a substantial public health burden due to its high incidence, rendering it an urgent medical concern. Emerging evidence suggests that cellular senescence and circadian rhythms are closely linked to the onset of cerebral infarction and may represent promising therapeutic targets. Accordingly, we retrieved datasets GSE16561 and GSE22255 from the Gene Expression Omnibus and extracted cellular senescence- and circadian rhythm-related genes from the GeneCards database. Through bioinformatics analysis, we identified key targets associated with cellular senescence and circadian rhythm in cerebral infarction, specifically CREBBP, FOS, CDK4, MMP9, PTEN, and HIF1A. Complementing these findings with in vitro experiments, our results demonstrate that the expression of these genes and proteins at these core targets are elevated to varying degrees in an in vitro model of cerebral infarction. These findings provide compelling evidence supporting the pivotal role of cellular senescence- and circadian rhythm-related genes in the pathogenesis of ischemic stroke.

Source: Medicine

DOI: 10.1097/md.0000000000043220

Authors: Fukang Zeng, Mengjuan Wang, Menghao He, Zhong Li, Yuxing Zhang

Institutions: Hunan University of Traditional Chinese Medicine, First Affiliated Hospital of Hunan University of Traditional Chinese Medicine, The University of Texas Health Science Center at Houston

Language: English

Topic: Acute Ischemic Stroke Management

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,950