Figure 3 from Impact of Glucocorticoids on Immune Checkpoint Inhibitor Efficacy and Circulating Biomarkers in Non–Small Cell Lung Cancer Patients
Year: 2025
Type: other
Abstract: Impact of steroids on CD8+ T-cell differentiation and predictive value of the CX3CR1 score in patients with NSCLC treated with ICI therapy. A, Violin plot with median (red solid line) and the top and bottom quartiles (red dotted line) showing the frequency of PB CX3CR1+ CD8+ T cells in patients who were or were not on steroids at baseline. P value was calculated by a two-tailed Mann–Whitney U test. B, ORR for patients who were or were not on steroids at baseline and the maximal percent change of the CX3CR1+ subset among PB CD8+ T cells from baseline (CX3CR1 score) at 9 weeks. The ORR was analyzed by the Fisher exact test. C, CX3CR1 score in responders (CR/PR) and nonresponders (SD/PD) who were or were not on steroids at baseline. The non-steroid group was separated into anti–PD-1 therapy (black line) and chemo-immunotherapy (red line). CR, complete response; PD, progressive disease; PR, partial response; SD, stable disease.
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4412087581