Regarding the Model of a Disease X Pandemic Requiring a Higher Priority in Ensuring Biological Safety
Year: 2025
Type: article
Abstract: The aim of the work was to create an analytical model of a test disease X pandemic that requires a priority approach to ensuring biological safety, using COVID-19 and influenza as an example. The created pandemic model consists of 2 elements: the pandemic phenomenon itself using COVID-19 as a case study and the post-pandemic period using the Spanish flu as an example. The formalized structure, signs, parameters, properties and negative consequences of the COVID-19 pandemic as a phenomenon with an extraordinary scale of epidemic spread, socio-economic and other critical consequences that disorganize society, comparable with threats to national and international security, the readiness for which is a part of ensuring biological safety in a broad format, have been determined using the epidemiological method, the law of large numbers (LLN in probability theory), and the global application of digital and genomic technologies. An in-depth study of the COVID-19 pandemic has revealed the value of a certain structure of the clinical and epidemiological content of the epidemic phase of the pandemic, which determined the high quantitative parameters of spread and mortality. A 10-fold range of change in the key criterion, both upward and downward, has been established, which is incompatible with the emergence and existence of a pandemic as a phenomenon. The proof of the effectiveness, efficiency, scientific and practical significance of the COVID-19-based disease X pandemic model is the full implementation of the epidemiological forecast of COVID-19 pandemic duration in 2024 that we have developed for all its elements and parameters. The imitation of the post-pandemic period of disease X is represented by data on the circulation of the H1N1 influenza virus for more than 100 years, seasonal outbreaks and epidemics between 1920 and 1957, four moderate pandemics relative to the “Spanish flu” after 1957, and the production of particularly pathogenic potentially epidemic variants of the influenza virus. In general, the model is proposed to be used to monitor and assess preparedness for future pandemics in the format of biological disasters when forming state policy in the field of biological safety, as well as to prevent the occurrence of emergencies within the framework of the implementation of the International Health Regulations (2005).
Institution: Russian Scientific Research Institute Microbe
Language: English
Subfield: Sociology and Political Science
Field: Social Sciences
Domain: Social Sciences
Open Access status: diamond
OpenAlex ID: W4412095649