Econazole Nitrate Nanogels Formulated and Evaluated by Modified Emulsification Diffusion Technique to Treat Candidiasis
Year: 2025
Type: article
Abstract: When using econazole nitrate in conventional drug delivery. This can waste the drug, reduce its bioavailability, and cause some side effects. A condition that can range from superficial to deeply invasive and systemic invasions, caused by infection with Candida species. In the current work, we created a nanogel using a modified emulsification diffusion method as a potentially effective topical drug delivery system for econazole nitrate. We then assessed the econazole nitrate using a number of parameters, including extrudability, spreadability, drug content, and physical appearance. Because of the polymers used, the in vitro release complied with zero order kinetics, exhibiting a release erosion mechanism followed by non-Fick Ian diffusion. Drug administration frequency can be decreased, bioavailability can be increased, and side effects can be decreased.
Authors: {"name":"Lakshmi Sarada Sagi","email":"[email protected]","affiliation, {"name":"Manjula Chella","email":"[email protected]","affiliation":"As, {"name":"Ranjitha Shiva Prakash","email":"[email protected]","affiliati, {"name":"Madhusudhan Reddy Bijivemula","email":"[email protected]","affili, {"name":"Kaviyarasan Sakthi","email":"[email protected]","affiliation":"Va, {"name":"Vamsidhar Reddy Obili","email":"[email protected]","affiliation, {"name":"Venkata Chalapathi Palla","email":"[email protected]","affili, {"name":"Pradeep Kumar Mutcherla","email":"[email protected]","affilia
Language: English
Subfield: Pharmaceutical Science
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4412099366