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Unlocking ESCC Progression: CCL15-CCR1 Axis Activates AKT/ERK1/2/c-Jun/CDK2 Pathway

Year: 2025

Type: article

Abstract: CCL15-CCR1-mediated phosphorylation of c-Jun through the AKT/ERK1/2 pathway. In addition, we conducted a drug screening targeting CCR1 and identified Jervine as a potential CCR1 degrader. In summary, this study uncovers the relationship between CCL15-CCR1 axis and ESCC progression and provides insights into potential therapeutic strategies targeting this pathway.

Source: Journal of Cancer

DOI: 10.7150/jca.113925

Authors: Shengliang He, Yunjiu Gou, Qizhou Bo, Dacheng Jin, Songchen Han, Hui Cai

Institutions: Gansu Provincial Hospital, Lanzhou University

Language: English

Topic: Chemokine receptors and signaling

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,337