Work

[Single-cell analysis of immune-lineage features in T-cell large granular lymphocytic leukemia].

Year: 2025

Type: other

Abstract: T-LGLL patients present a characteristic immunological profile marked by an imbalance in immune homeostasis. This profile includes abnormal activation and expansion of effector CD8(+) T cells, and a reduction in Treg cell numbers accompanied by functional impairment. Furthermore, APCs and NK cells were found to positively regulate T-lymphocyte activation, differentiation, and proliferation.

Source: PubMed

DOI: 10.3760/cma.j.cn121090-20241125-00479