Work

Clomiphene-induced myocardial infarction in a young male: A case report of a rare cardiovascular complication

Year: 2025

Type: article

Abstract: Clomiphene citrate is commonly prescribed to treat male hypogonadism due to its ability to increase endogenous testosterone levels while preserving fertility. Although it is generally considered safe, and rare serious cardiovascular events have been reported. We present the case of a male in his early 30s with no known cardiovascular risk factors who developed an acute inferior-posterior ST-elevation myocardial infarction while taking clomiphene for infertility. Coronary angiography revealed complete occlusion of the distal right coronary artery due to a heavy thrombus burden, with no underlying atherosclerotic disease. The patient was successfully treated with aspiration thrombectomy and conservative medical management. This case underscores a potential, albeit rare, association between clomiphene use and myocardial infarction, warranting caution in its use-even among individuals without traditional cardiovascular risk factors.

Source: Science Progress

DOI: 10.1177/00368504251349392

Authors: Zubair Shahid, Gi Eun Kim, Tariq Mousa, Ziad AlSehli, Awad Al-Qahtani

Institution: Hamad Medical Corporation

Language: English

Topic: Acute Myocardial Infarction Research

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,650