Work

Case Commentary: Overcoming intrinsic resistance—the successful use of aztreonam and avibactam for Stenotrophomonas maltophilia meningitis

Year: 2025

Type: editorial

Abstract: ABSTRACT Wong-So and colleagues describe a case of post-neurosurgical Stenotrophomonas maltophilia meningitis successfully managed with ceftazidime-avibactam and aztreonam. While aztreonam is stable against L1 metallo-β-lactamase-mediated hydrolysis, it remains susceptible to L2 serine β-lactamases, which are effectively inhibited by avibactam, restoring aztreonam’s bactericidal activity. Simultaneous peak and trough levels in cerebrospinal fluid (CSF) and plasma demonstrated favorable CSF-to-plasma ratios for both aztreonam and avibactam. This case highlights aztreonam-avibactam as a rational therapeutic strategy for S. maltophilia meningitis.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.00640-25

Authors: Alice J. Hsu, Pranita D. Tamma

Institutions: Johns Hopkins University, Johns Hopkins Hospital, Johns Hopkins Medicine

Language: English

Topic: Infections and bacterial resistance

Subfield: Endocrinology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4412116768

Cites: 22

Cited by: 1

Related to: 10