Impact of Residential Greeness Exposure on the Development of Allergic Diseases and Asthma and on Asthma Control—A Systematic Review for the EAACI Guidelines of Environmental Science for Allergic Diseases and Asthma
Year: 2025
Type: review
Study designs: Systematic Review, Meta-Analysis
Abstract: The role of residential greenness exposure (RGE) in prevention and control of allergic diseases remains controversial. This systematic review evaluated the association between RGE and the risk of developing asthma, allergic rhinitis (AR), food allergy, atopic dermatitis (AD), and asthma control. MEDLINE and EMBASE searches retrieved 17 cohort and case-control longitudinal studies (12 for asthma, 6 AR, 1 food allergy, 1 ad). Risk of bias was assessed with ROBINS-E, and certainty of evidence with GRADE. Data were meta-analyzed using adjusted odds ratios (aORs) with random-effects models. For "ever asthma" and "ever AR" a non-significant protective trend of RGE was observed (aOR 0.92, 95% CI 0.72-1.18; aOR 0.61; 95% CI 0.24-1.55). For "current asthma" RGE was associated with increased risk (aOR 1.17, 95% CI 1.04-1.33), with no clear association for "current AR" (aOR 1.03; 95% CI 0.80-1.32). Prenatal RGE reduced the risk of "ever asthma" (aOR 0.94, 95% CI 0.93-0.950) and AD (aOR 0.996, 95% CI 0.993-0.999). RGE increased the risk for peanut (aOR 1.78, 95% CI 1.13-2.82) and egg allergy (aOR 1.38, 95% CI [1.05-1.82]). Reduced RGE decreased asthma control (OR: 2.662, 95% CI [1.043-6.799]). Potential benefits or potential harms of RGE should be judged in a context-specific manner.
Source: Allergy
DOI: 10.1111/all.16653
Authors: Ioana Agache, Graciela J. Balbin‐Ramon, Fiorella Karina Fernandez Saenz, Ivan Sola‐Arnau, Pablo Alonso‐Coello, Tari Haahtela, Claudia Traidl‐Hoffmann, Liam O'Mahony, Athanasios Damialis, Antti Lauerma, Kari C. Nadeau, Isabella Pali‐Schöll, Oscar Palomares, Harald Renz, Jurgen Schwarze, Donata Vercelli, Carlos Canelo‐Aybar, Marek Jutel, Cezmi A. Akdis
Institutions: Transilvania University of Brașov, Iberoamerican Cochrane Centre, Hospital de Emergencias Jose Casimiro Ulloa, Institut de Recerca Sant Pau, Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, University of Helsinki, Helsinki University Hospital, University of Augsburg, National University of Ireland, APC Microbiome Institute, Aristotle University of Thessaloniki, Harvard University, University of Veterinary Medicine Vienna, Medical University of Vienna, Universidad Complutense de Madrid, Tongji University, Philipps University of Marburg, German Center for Lung Research, Universities of Giessen and Marburg Lung Center, Kilimanjaro Christian Medical Centre, Centre for Inflammation Research, University of Edinburgh, University of Arizona, BIO5 Institute, Wroclaw Medical University, All-Med, University of Zurich
Language: English
Topic: Urban Green Space and Health
Subfield: Urban Studies
Field: Social Sciences
Domain: Social Sciences
Open Access status: bronze
OpenAlex ID: W4412118348