Work

From Nature to Nanotechnology: The Bioactivities of Mangiferin Explored

Year: 2025

Type: review

Abstract: : Mangiferin, a naturally occurring C-glucosylxanthone derived from various parts of the mango tree ( Mangifera indica ), has gained significant attention for its diverse pharmacological properties, including antioxidant, anti-inflammatory, antimicrobial, anticancer, and anti-diabetic activities. This mini-review provides an updated overview of the phytochemistry, pharmacokinetics, and medicinal properties of mangiferin. However, the low solubility (0.111 mg/mL) and oral bioavailability (less than 2%) of mangiferin pose significant challenges for its clinical application. To address these issues, the development of nanoformulations such as nanoparticles, micelles, and liposomes has been explored, which was proven to improve mangiferin’s solubility, stability, and targeted delivery. These nanocarriers enhance the bioavailability and therapeutic efficacy of mangiferin, making it a promising candidate for various therapeutic applications. The review ends with the discussion of the safety of mangiferin and its formulations in addition to the potential for clinical translation. Keywords: mangiferin, phytochemistry, anticancer, antioxidant, inflammation, neurodegenerative diseases

Source: Nanotechnology Science and Applications

DOI: 10.2147/nsa.s525423

Author: Haitham Al-Madhagi

Institution: Thamar University

Language: English

Topic: Mangiferin and Mango Extracts

Subfield: Complementary and alternative medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,320