Work

A Contemporary Review of Thoracic Aortic Aneurysm: From Molecular Pathogenesis to Clinical Integration

Year: 2025

Type: article

Abstract: Aortic aneurysm is a vascular disease with a complex pathogenesis which is usually asymptomatic but can lead to high mortality with sudden rupture. This review comprehensively examines the molecular mechanisms of aortic aneurysms in the context of extracellular matrix destruction, smooth muscle cell apoptosis, chronic inflammation, oxidative stress, genetic mutations, and epigenetic regulations. In addition, the potential of molecular biomarkers in diagnosis and prognosis and targeted treatment strategies are evaluated. Animal models and translational findings form the basis for establishing a bridge between preclinical and clinical applications. This study aims to provide insight into the integration of molecular findings into clinical practice in light of the current literature and to guide future research.

Source: Journal of Vascular Diseases

DOI: 10.3390/jvd4030026

Authors: İsa Ardahanlı, Ramazan Aslan, Halil İbrahim Özkan, Faik Özel, Murat Özmen

Institutions: Bilecik Şeyh Edebali Üniversitesi, Balıkesir University, Erzurum Regional Training and Research Hospital

Language: English

Topic: Aortic Disease and Treatment Approaches

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,207