A novel 1,8-naphthalimide-piperazine-amidobenzenesulfonamide derivative targets carbonic anhydrase IX to induce ferroptosis, apoptosis and autophagy in colorectal cancer cells
Year: 2025
Type: article
Abstract: of 38.83 ± 1.98 μM. Compound Q also inhibits tumour growth in the colorectal cancer SW480 xenograft model and it shows no adverse effects on nude mice body weight. Our analyses also demonstrate that compound Q induces ferroptosis, apoptosis and autophagy in colorectal cancer and we believe that these are the main mechanisms by which it promotes cell death in this cancer. Taken together, our data indicate that compound Q is a potent and selective CA IX inhibitor that is promising for the treatment of colorectal cancer.
Source: RSC Medicinal Chemistry
DOI: 10.1039/d5md00348b
Authors: Xiao-Qun Zhou, Yong-Xiao Huang, Qiao-Ling Liang, Ri-Zhen Huang, Ye Zhang, Hai-Rui Lu, Xian-Li Ma, Nur Syamimi Ariffin
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W4412200981