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Iodine-promoted oxidative cross-coupling for the synthesis of ( E )-2-(3-oxo-3-phenylprop-1-en-1-yl)-3-phenylquinazolin-4(3 H )-one via C–H activation: development of synthetic TLX agonists

Year: 2025

Type: article

Abstract: )-ones under mild conditions, delivering high selectivity and excellent yields. The reaction offers a significant advancement in constructing highly conjugated systems, providing a streamlined and sustainable alternative to traditional synthetic approaches. Beyond the innovative chemistry, the synthesized compounds demonstrated agonistic activity for TLX, an orphan nuclear receptor crucial for neural stem cell proliferation, development, and disease. These findings highlight the dual importance of the methodology in enabling sustainable synthesis and the biological relevance of the resulting compounds as potential therapeutic tools.

Source: Organic & Biomolecular Chemistry

DOI: 10.1039/d5ob00672d

Authors: Lingaiah Maram, Puhan Zhao, Thomas Koelblen, Lamees Hegazy, Thomas P. Burris, Bahaa Elgendy

Institutions: University of Health Sciences and Pharmacy, Washington University in St. Louis, University of Florida Health, University of Florida

Language: English

Topic: Catalytic C–H Functionalization Methods

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Funder: Washington University School of Medicine in St. Louis

OpenAlex ID: W4412203445

FWCI: 0.289

Cites: 57

Cited by: 1

Related to: 10