Work

Comparison of LNR- and LODDS-based predictive models for prognosis in non-elderly patients with locally advanced rectal cancer undergoing neoadjuvant therapy

Year: 2025

Type: article

Abstract: PURPOSE: The purpose of this study was to comprehensively assess the efficacy of lymph node ratio (LNR) and log odds of positive lymph nodes (LODDS) in predicting survival outcomes in non-elderly locally advanced rectal cancer (LARC) patients treated with neoadjuvant chemoradiotherapy (NCRT). METHODS: The 1643 non-elderly LARC patients undergoing NCRT between 2010 and 2015 were extracted from the Surveillance, Epidemiology, and End Results (SEER) database and were randomly assigned at a ratio of 7:3. We used Cox regression models to identify independent prognostic factors, then constructed nomogram models to predict cancer-specific survival (CSS) and overall survival (OS). The relative weight in nomogram models, receiver operating characteristic (ROC), area under the curve (AUC), concordance index (C-index), calibration curve, and decision curve analysis (DCA) were performed to evaluate and compare the predictive performance between LNR and LODDS. RESULTS: The distribution of LNR and LODDS showed that LODDS exhibited a more detailed stratification when LNR was equal to the extreme value. In predicting CSS, the LNR (hazard ratio (HR), 1.987; 95% confidence interval (CI), 1.375-2.872) and LODDS (HR, 1.568; 95% CI, 1.154-2.131) were independent risk factors in corresponding nomogram models. Regarding OS, the LODDS (HR, 1.387; 95% CI, 1.060-1.816) showed an independent predictive value. All evaluation methods confirmed the reliability of both models. Although the LNR-based model showed better performance for short-term CSS and the LODDS-based model demonstrated slightly better prediction for long-term CSS and OS, these two models showed largely comparable predictive ability. CONCLUSIONS: The LNR and LODDS can provide complementary prognostic value in survival prediction, offering clinicians a comprehensive basis for clinical decision-making.

Source: International Journal of Colorectal Disease

DOI: 10.1007/s00384-025-04942-6

Authors: Wei Tao, Yuxi Cheng, Peng Wang, Hong Wen, Weidong Xiao

Institutions: Army Medical University, Xinqiao Hospital, Fudan University, Zhongshan Hospital

Language: English

Topic: Colorectal Cancer Surgical Treatments

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,790