Albumin-Bilirubin Score for Predicting the in-Hospital Mortality of Acute Upper Gastrointestinal Bleeding in Liver Cirrhosis
Year: 2025
Type: article
Study design: Observational Study
Abstract: Introduction: Acute upper gastrointestinal bleeding (AUGIB) is a serious complication of liver cirrhosis with significant mortality. Early risk stratification is crucial. This study aimed to evaluate the diagnostic accuracy of the Albumin-Bilirubin (ALBI) score in predicting in-hospital mortality among cirrhotic patients presenting with AUGIB. Methodology: A descriptive longitudinal study was conducted on 180 patients with liver cirrhosis and AUGIB. The ALBI score was calculated using serum albumin and bilirubin levels. Receiver operating characteristic (ROC) analysis was performed to assess the predictive value of the ALBI score, with stratification based on gender, age, diabetes, hypertension, cirrhosis duration, hospital stay, and Child-Pugh class. Results: The ALBI score showed good overall predictive accuracy with an AUC of 0.816 (95% CI: 0.74–0.89, p=0.001). The optimal cut-off value was -1.50, yielding 90.9% sensitivity and 66.7% specificity. Stratified analysis showed the best performance in females (AUC 0.907), patients aged ≤50 years (AUC 0.850), and diabetics (AUC 0.830). High sensitivity was maintained across most subgroups. Conclusion: The ALBI score is a simple, objective, and reliable tool for predicting in-hospital mortality in cirrhotic patients with AUGIB. It can aid in early risk stratification and clinical decision-making.
Authors: Ali Raza, Abdul Aziz Sahito, Riaz Hussain Khokhar, Waseem Raja Memon, Ali Kashif Malik, Khawar Hussain
Language: English
Subfield: Hepatology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4412355221