Curvulomycin E, a New Resorcylic Acid Lactone From the Beibu Gulf Coral‐Derived Fungus Curvularia lunata GXIMD 02512
Year: 2025
Type: article
Abstract: ABSTRACT One new resorcylic acid lactone (RAL), curvulomycin E (1), along with 10 known compounds (2–11), was obtained from the Beibu Gulf coral‐derived fungus Curvularia lunata GXIMD 02512. Their structures were determined by extensive spectroscopic data interpretation and comparison with literature. The absolute configurations of 1 and 10 were accomplished by ECD calculations. Structurally, curvulomycin E (1) with a methoxy substituent at C‐12 is generally uncommon in the 12‐membered RAL family. Compounds 2–4 exhibited cytotoxicity against MDA‐MB‐231 and KTC‐1 cells with IC50 values ranging from 10.8 to 26.5 μM. The preliminary structure–activity relationship is discussed. Compound 2 further arrested the cell cycle at the S phase and dose‐dependently induced apoptosis in MDA‐MB‐231 cells.
Source: Magnetic Resonance in Chemistry
DOI: 10.1002/mrc.70014
Authors: Guihua Yang, Xinjian Qu, Hong Zhang, Chaonan Wang, Miaoping Lin, Xin Qi, Chenghai Gao, Yonghong Liu, Xiaowei Luo
Language: English
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Awards: G2536795245, G5125864067
OpenAlex ID: W4412360261