Year: 2025
Type: article
Abstract: Preterm birth is one of the biggest problems of modern obstetrics, as it significantly affects the health of both the mother and the newborn. According to the World Health Organization, preterm birth is one of the leading causes of infant mortality in the world. The pathophysiology of preterm labor is a complex multifactorial process that includes the interaction of infectious and inflammatory reactions, hormonal disorders, genetic factors, and physiological changes in a woman’s body.An important aspect is that urinary tract infections, urogenital infections, and inflammatory processes in the uterus can initiate the release of pro-inflammatory mediators such as interleukins and prostaglandins, which activate uterine contractions and lead to premature labor.Hormonal disorders, in particular, a decrease in progesterone levels or disruption of its receptors, are an important factor in the development of this pathology. Genetic factors that determine individual predisposition to this pathology may also play a role in the development of preterm labor. In addition, impaired cervical integrity, such as cervical insufficiency or shortness, significantly increases the likelihood of preterm birth.Socio-environmental factors, such as stress, poor nutrition, and environmental pollution, also play an important role in the occurrence of preterm birth.Since preterm birth is a complex and multifaceted process, research into the pathophysiology of this pathology is essential for the development of effective methods of diagnosis, treatment and prevention. To date, significant advances in the use of progesterone, prostaglandin inhibitors, and ultrasound diagnostics have reduced the risk of preterm birth, but further research remains important to improve treatment strategies and reduce the rate of premature mortality among newborns.
Authors: Yu.S. Oliferuk, P.Yu. Tokar
Institution: Bukovinian State Medical University
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4412362096