Year: 2025
Type: article
Abstract: In this study, a porous Ti-25Ta alloy scaffold was fabricated using 3D printing and compared with pure Ti to evaluate its biocompatibility and osteogenic potential. The scaffolds were fabricated using a selective laser melting (SLM) process, followed by investigations of physical properties, in vitro cytocompatibility, osteogenesis, macrophage polarization, and in vivo bone reconstruction. Pure Ti exhibits the highest wettability, cell proliferation, osteogenic differentiation, mineralized nodule formation, anti-inflammatory capability, and bone reconstruction. The adoption of Ta in the Ti-25Ta alloy significantly increases its wettability, osteogenesis, and anti-inflammatory without a great increase in density. In summary, the Ti-25Ta alloy has a favorable balance of physical properties and biological performance, making it a promising candidate as a bone implant material.
Source: Discover Applied Sciences
Authors: Di Wu, Yada Li, Wangwei Zhu, Haolin Jiao, Bing Ge, Qinwen Xie, Jianfeng Xu, Weidan Wang, Fang Cao, Guangxiao Yin, Junlei Li, Dewei Zhao
Institution: Affiliated Zhongshan Hospital of Dalian University
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: diamond
Awards: G4569766450, G8015945037
OpenAlex ID: W4412364395