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Development and Evaluation of a Bifunctional Metronidazole and Bmp-2 Controlled Release Scaffold for Periodontal Regeneration

Year: 2025
Type: article
Abstract: Periodontitis is a common inflammatory periodontal disease characterized by the destruction of bone tissue and requires an integrated treatment approach. In this study, an intelligent scaffold based on a collagen-hyaluronic matrix was developed that provides pH-dependent metronidazole release and prolonged delivery of recombinant bone morphogenetic protein-2 (rhBMP-2). Scaffold demonstrated pronounced antimicrobial activity against Porphyromonas gingivalis and Aggregatibacter actinomycetemcomita
DOI: 10.51847/0ikeecizxu
Authors: Ayza Fedarovna Taysaeva, Milana Alimbekovna Makieva, Ayshat Magomedovna Khubieva, Dzerassa Alanovna Khugaeva, Patimat Alievna Tayburova, Khasan Akhyadovich Satuev, Daria Dmitrievna Karpeeva, Daria Andreevna Onishchenko
Institutions: North Ossetian State Medical Academy, North Caucasian State Academy, Dagestan State Medical University, Kabardino-Balkarian State University, Saratov State Medical University, Stavropol State Medical University
Language: English
Subfield: Urology
Field: Medicine
Open Access status: hybrid
OpenAlex ID: W4412365013
FWCI:
Cites: 69
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Related to: 10