Year: 2025
Type: article
Study design: Case Report
Abstract: Punctate Palmoplantar Keratoderma Type 1 (PPKP1) is a rare genetic disorder characterized by autosomal dominant inheritance, manifesting as punctate keratotic papules on the skin of the palms and soles. This report discusses a new case of this condition to underscore the rarity of this dermatosis. Recent research has identified mutations in the AAGAB gene as the cause of PPKP1, explaining its familial patterns. Treatment typically includes surgical excision of hyperkeratotic papules, supplemented by low-dose oral retinoids and topical applications of urea and salicylic acid to reduce symptom recurrence.
Source: Journal of Dermatology Research
Authors: Meryem Khalidi, H Kerrouche, Y Zemez, M Amraoui, J Azhari, T Hanafi, R Frikh, N Hjira
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W4412365572