Work

Depth-dependent fluence compensation without a priori knowledge of tissue composition for quantitative ultrasound-guided photoacoustic imaging

Year: 2025

Type: article

Abstract: Significance: knowledge of tissue composition is a crucial unmet need for quantitative photoacoustic imaging. Aim: We developed a method for estimating the effective optical attenuation coefficient of bulk tissue with composition and optical properties that are not known in advance, through combined ultrasound/photoacoustic imaging during mechanical displacement of tissue. Approach: Ultrasound/photoacoustic imaging was performed on a target embedded in biological media while applying tissue displacement to change the optical path. After compensation for geometry-dependent scattering of light from light source apertures, the change of photoacoustic amplitude against optical path length was used to estimate the effective optical attenuation coefficient. Results: porcine muscle and chicken breast was accurate compared with ground-truth literature values. Conclusions: Regardless of the varying geometries used for light delivery in photoacoustic imaging, it is feasible to perform ultrasound-guided photoacoustic imaging with simultaneous mechanical displacement of tissue to determine the effective optical attenuation coefficient of bulk tissue along the light path to the target.

Source: Journal of Biomedical Optics

DOI: 10.1117/1.jbo.30.7.076005

Authors: David Qin, Xinyue Huang, Timothy Sowers, Donald VanderLaan, Stanislav Emelianov

Institutions: Georgia Institute of Technology, Emory University, The Wallace H. Coulter Department of Biomedical Engineering

Language: English

Topic: Photoacoustic and Ultrasonic Imaging

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,675