Get started
Work

How macrophages use extracellular calreticulin to chase their prey

Year: 2025
Type: editorial
Abstract: Recent findings reveal that macrophages actively control clearance by desialylating target cells via NEU1 and releasing cathepsin-cleaved calreticulin (CALR) to mark them for phagocytosis. This uncovers a dual role for CALR as immune activator or repressor, depending on its form and context, with distinct implications for cancer immunity.
DOI: 10.1080/2162402x.2025.2533494
Language: English
Subfield: Immunology
Open Access status: gold
Estimated APC paid: $2,913
Funders: Association pour la Recherche sur le Cancer, Seerave Foundation, Agence Nationale de la Recherche, Fondation pour la Recherche Médicale, Ligue Contre le Cancer, Institut National Du Cancer, Cancéropôle Ile de France, Fondation Gustave Roussy, HORIZON EUROPE European Innovation Council
Awards: Next-generation phenotypic screening for oncological applications, Lung cancer prevention and interception, Mitochondrial copper targeting to modulate inflammatory macrophages, Microbiota-centered interventions to solve antibiotics-induced primary resistance to immune checkpoint inhibitors, Energizing the failing heart, Université de Paris, The RUSH (retention using selective hooks) system: a chemical-genetic system for the in vivo manipulation of intercellular communication
OpenAlex ID: W4412366342
Cites: 10
Cited by: 3
Related to: 10