Work

Concurrent triple viral co-infection in a patient with metastatic renal cell carcinoma: A case report

Year: 2025

Type: article

Abstract: There are limited reports of concomitant infection with hepatitis B virus, Epstein-Barr virus, and cytomegalovirus. This case represents the first documented instance of such a triple infection in an individual with metastatic renal cell carcinoma undergoing combined immunotherapy with ipilimumab and nivolumab. This is the case of a 40-year-old male patient with past medical history notable for type 1 diabetes mellitus and renal cell carcinoma who exhibited liver function abnormalities suggestive of viral liver injury, particularly due to hepatitis B virus reactivation. Interestingly, despite the triple infection, the patient experienced relatively mild disease progression, with liver function tests showing a downward trend, likely due to timely intervention with tenofovir. This case highlights the complexity of viral interactions in immunocompromised patients and emphasizes the need for further research into optimal management strategies.

Source: SAGE Open Medical Case Reports

DOI: 10.1177/2050313x251356397

Authors: Fariha Hasan, Umm E. Salma Shabbar Banatwala, Tanay-Veer Gandhi, Polina Gaisinskaya, Cristina Capanescu

Institutions: Cooper University Hospital, Dow University of Health Sciences, Cooper Medical School of Rowan University

Language: English

Topic: Cytomegalovirus and herpesvirus research

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,000