Atypical Presentation of Pulmonary Carcinoid Tumor With Pleural Involvement: Diagnostic and Surgical Challenges
Year: 2025
Type: article
Study design: Case Report
Abstract: This case report presents a diagnostically challenging pulmonary typical carcinoid tumor with localized pleural involvement, initially misdiagnosed intraoperatively as small cell carcinoma. Despite the presence of pleural nodules, typically staged as M1a disease, histopathology confirmed a low-grade neuroendocrine tumor with favorable features, including a low Ki-67 index and absence of necrosis. Somatostatin receptor imaging using 68Ga-DOTATATE positron emission tomography/computed tomography (PET/CT) revealed no distant spread. The patient underwent definitive surgical management with lobectomy, pleurectomy, and lymph node dissection. Postoperative recovery was uneventful, and the patient remains disease-free. This case highlights the limitations of frozen section diagnosis in neuroendocrine tumors and challenges the prognostic implications of pleural involvement in typical carcinoid tumors. Individualized surgical decisions based on tumor biology, rather than rigid staging criteria, may be warranted.
Source: Cureus
DOI: 10.7759/cureus.87822
Authors: Ayushi Sen, Ahmad Bahay, Shagun Thakur, Salma Gonzalez, Michael Zemaitis, Loren J Harris
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4412372085