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An Interesting Case of Anti-Small Ubiquitin-Like Modifier-Activating Enzyme (SAE) Antibody-Positive Dermatomyositis

Year: 2025

Type: article

Abstract: Dermatomyositis (DM) is a heterogeneous autoimmune disease characterized by inflammatory involvement of the skin and muscles. Anti-small ubiquitin-like modifier activating enzyme (SAE) antibodies define a rare clinical subtype of DM, often associated with prominent cutaneous findings and systemic features such as dysphagia. This report presents the case of a 45-year-old male with steroid-refractory, anti-SAE-positive DM, highlighting the diagnostic and therapeutic challenges of this condition and underscoring the importance of early recognition and personalized management.

Source: Cureus

DOI: 10.7759/cureus.87833

Authors: Smrithi Suresh, Suresh Kumar, Bhargavi M V, Srinivasan Ramadurai, Rajkumar Mani

Institution: Sri Ramachandra Institute of Higher Education and Research

Language: English

Topic: Inflammatory Myopathies and Dermatomyositis

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4412373118