Work

Adult-Onset Still’s Disease in a 49-Year-Old Female in the UAE: A Case Report and Literature Review

Year: 2025

Type: article

Abstract: Adult-onset Still's disease (AOSD) is a rare autoinflammatory disorder characterized by high spiking fevers, salmon-colored rash, arthritis, and hyperferritinemia. It often mimics infections or autoimmune conditions, leading to diagnostic delays. We report a case of a 49-year-old female who presented with fever, fatigue, arthralgia, evanescent rash, and elevated inflammatory markers. Extensive infectious and autoimmune workups were negative. Her serum ferritin exceeded 16,000 ng/mL. She fulfilled the Yamaguchi criteria for AOSD, and treatment with corticosteroids followed by tocilizumab resulted in marked clinical improvement. This is, to our knowledge, the first documented case of AOSD from the UAE. It underscores the importance of ferritin in diagnosis and disease monitoring and highlights the efficacy of interleukin (IL)-6 inhibition in management.

Source: Cureus

DOI: 10.7759/cureus.87858

Authors: Nagwa M Ali, Mohammed O Ibrahim, Osama M Mohamed

Institutions: Mohammed Bin Rashid University of Medicine and Health Sciences, Abu Dhabi Health Services

Language: English

Topic: Autoimmune and Inflammatory Disorders Research

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4412377779