Work

Supratherapeutic International Normalized Ratio with Concomitant Warfarin and Cupric Chloride (Copper) Therapy

Year: 2025

Type: article

Abstract: We report a case of supratherapeutic international normalized ratio values in a hospitalized patient started on warfarin to prevent recurrent deep vein thrombosis. Her medical history showed a failed course of apixaban and so warfarin therapy was initiated during this admission but quickly stopped after sudden, significant increases in international normalized ratio for several days after termination of therapy. A review of any drug-drug interaction did not expose any reported interactions between warfarin and her current medications at that time. However, the concurrent administration of cupric chloride did raise the possibility of an undocumented interaction between these two entities. The pharmacokinetic/pharmacodynamic properties of both drugs provided a study into the consequences of a combination therapy, beyond the anticipated outcome, which is normally based on previously observed results.

Source: Case Reports in Clinical Medicine

DOI: 10.4236/crcm.2025.147042

Authors: Jan Maxa, Rashed Khaleque, Scott Massey

Institution: Baylor University Medical Center

Language: English

Topic: Venous Thromboembolism Diagnosis and Management

Subfield: Internal Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4412381726