Work

Digestive autoimmune diseases mimicking gastrointestinal manifestations in children with sickle cell anemia: A report of three cases

Year: 2025

Type: article

Abstract: Sickle cell anemia (SCA) is a genetic disorder that presents with a variety of systemic complications, including gastrointestinal (GI) manifestations. These GI symptoms can overlap with those of digestive autoimmune diseases (DAD) such as inflammatory bowel disease (IBD) and autoimmune hepatitis (AIH), complicating the diagnosis and management. This study presents three cases of SCA patients diagnosed with DAD, highlighting the diagnostic challenges and therapeutic outcomes. Our goal is to stress how abdominal symptoms in SCA can mask the presence of DAD, leading to potential misdiagnoses. We review the implications of these findings in clinical practice and compare them to the literature to emphasize the importance of recognizing and differentiating these conditions to avoid delays in treatment.

Source: JPGN Reports

DOI: 10.1002/jpr3.70062

Authors: Saray Mesonero Cavia, Marta García Bernal, Maria Jose López Liñan, Roger García Puig

Institutions: Hospital Terrassa, University Hospital Mútua de Terrassa, Mútua Terrassa, Consorci Sanitari de Terrassa

Language: English

Topic: Hemoglobinopathies and Related Disorders

Subfield: Genetics

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $1,900