Multidimensional biocircuitry of exercise adaptation: integrating in vivo and ex vivo phenomics with miRNA mapping
Year: 2025
Type: article
Abstract: We examined in vivo and ex vivo adaptations to traditional moderate-intensity endurance and resistance training (TRAD) versus high-intensity tactical training (HITT; explosive whole-body interval training and high-intensity resistance training). TRAD and HITT improved physiological performance and body composition, and induced ex vivo muscle adaptations, with remarkable interindividual response heterogeneity (IRH) in improvements. We leveraged multidimensional modeling to identify interindividual response heterogeneity biocircuitry that integrates deep phenotyping and miR transcriptomics (serum exosomes and skeletal muscle).
Source: Physiological Genomics
Authors: Jeremy S. McAdam, Michael P. Craig, Zachary A. Graham, Brandon Peoples, S. Craig Tuggle, Regina S. Seay, Kaleen M. Lavin, Amber B. Gargus, Samia M. O’Bryan, Sufen Yang, Devin J. Drummer, Christian J. Kelley, Kalyani Peri, Margaret B. Bell, Inmaculada Aban, Gary R. Cutter, Arash Mahyari, Yuan Wen, Jin Zhang, Akshay Hira, Timothy J. Broderick, Madhavi P. Kadakia, Marcas M. Bamman
Language: English
Subfield: Complementary and alternative medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Award: G5943978800
OpenAlex ID: W4412397838