Work

Cell-free miRNA-150-5p serves as a biomarker and regulator of PROM-related preterm labor by targeting chorionic ADAM19

Year: 2025

Type: article

Abstract: MiR-150-5p is identified as a potential noninvasive biomarker associated with sPTL and regulates chorionic cell migration, invasion, and adhesion by targeting ADAM19, a member of the ADAM family, contributing to premature rupture of fetal membranes. These findings provide new insights into the molecular mechanisms of sPTL and suggest that targeting the miR-150-5p/ADAM19 axis may offer novel therapeutic strategies.

Source: American Journal of Physiology-Endocrinology and Metabolism

DOI: 10.1152/ajpendo.00045.2025

Authors: Ning Wang, Yuanyuan Liu, Kaiyi Sun, Bingying Chen, Yanyu Sui, Zhe Wang, Xiang Jiang, Li Li, Qin Li, Jingqiu Feng, Yi Tao, Lu Gao

Institutions: Second Military Medical University, Tongji University, Shanghai First Maternity and Infant Hospital, Changhai Hospital, Shanghai Jiao Tong University, Ruijin Hospital, Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics

Language: English

Topic: Preterm Birth and Chorioamnionitis

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: National Natural Science Foundation of China, Shanghai Municipal Education Commission, Institute of Zoology, Chinese Academy of Sciences, National Key Research and Development Program of China, Ferring Institute of Reproductive Medicine, Institute of Zoology, Chinese Academy of Sciences

Awards: G1714401454, G2028728220, G3508992455, G3852769010, G4039811522, G6251282041, G7025201818

OpenAlex ID: W4412398235

FWCI: 1.219

Cites: 45

Cited by: 2

Related to: 10