Work

CD105 as a Marker of Angiogenesis in Oral Squamous Cell Carcinoma – An Immunohistochemical Study

Year: 2025

Type: article

Abstract: Background: Oral squamous cell carcinoma (OSCC) is the most prevalent carcinoma of the head-and-neck region. Despite advanced tissue diagnosis, the survival period remains at 5 years. New molecular and cell markers are under investigation to improve survival rate. Objective: The objective of this study was to assess angiogenic activity by analyzing CD105 microvascular density (MVD) count in different histologic grades of OSCC. Subjects and Methods: Sixty samples are categorized into four groups. Immunohistochemical method with anti-CD105 was used for analyzing MVD. Results: The mean count of MVD is higher in OSCC than in normal mucosa and also significant among different histologic grades. A highly significant correlation is observed among different groups of OSCC samples. Conclusion: CD105 is a predictive marker for neoangiogenesis in OSCC.

Source: Contemporary Clinical Dentistry

DOI: 10.4103/ccd.ccd_521_24

Authors: Vijayalaxmi, Sunil S. Mishra, N. C. Sangamesh

Institutions: Dr. D.Y. Patil Vidyapeeth, Pune, Dr D Y Patil Dental College & Hospital, KIIT University

Language: English

Topic: Angiogenesis and VEGF in Cancer

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $250