Work

Hematology and reproductive performance of female rats supplemented with kelor (Moringa oleifera Lam.) leaf extract during the reproductive period

Year: 2025

Type: article

Abstract: Background: is an herbal plant with extensive potential for medical applications, including improving and enhancing animal health as well as reproductive performance. Aim: leaf extract (MOLE) supplementation on the hematological profile and reproductive performance of female rats during the prepregnancy to lactation period. Methods: An experimental study with a completely randomized design was conducted on nulliparous and sexually mature female Sprague-Dawley rats. The study consisted of four treatments and three to five replicates, namely control (feed without MOLE), MOLEE (feed containing MOL ethanol extract, MOLEF (feed containing MOL ethanol fraction), and MOLHE (feed containing MOL n-hexane extract). Observed variables included hematological values, estrogen, progesterone, prolactin, and oxytocin levels, litter size, prenatal mortality rate, birth weight, milk production, and pups' weight gain. Results: The results showed significant differences in most hematological parameters (white blood cell, red blood cell, hemoglobin, and hematocrit) and reproductive hormones (estrogen, progesterone, and prolactin levels). MOLE supplementation during pregnancy did not affect litter size and birth weight, but the MOLEE and MOLEF groups caused prenatal mortality. In addition, MOLE supplementation significantly increased milk yield but not pups' weight gain. Conclusion: MOLE supplementation positively affected the hematological values of female rats during the reproductive period and enhanced reproductive performance (reproductive hormone levels and milk production). However, it is essential to be aware of the possible adverse effects of prenatal mortality, which require further investigation to uncover the underlying causes and mechanisms.

Source: Open Veterinary Journal

DOI: 10.5455/ovj.2025.v15.i6.34

Authors: Fachruddin Fachruddin, Agik Suprayogi, Wasmen Manalu, Novriyandi Hanif, Huda Darusman

Institutions: IPB University, Institut Teknologi dan Kesehatan Avicenna

Language: English

Topic: Moringa oleifera research and applications

Subfield: Plant Science

Field: Agricultural and Biological Sciences

Domain: Life Sciences

SDGs: Good health and well-being, Zero hunger

Open Access status: gold

Estimated APC paid: $350