Year: 2025
Type: article
Abstract: Platelet-derived microparticles (PMPs) are extracellular vesicles (EVs) released by platelets when they are activated, undergo apoptosis, or are exposed to stress. These particles cannot be detected through routine platelet counting, and include proteins, lipids, RNAs and other substances. Their role in thrombosis and inflammation is well-established, but emerging evidences highlight their involvement in the pathogenesis and progression of hematological diseases. This review focuses on the current understanding of PMPs in diverse hematological diseases, including immune thrombocytopenia (ITP), acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), myeloproliferative neoplasms (MPNs), multiple myeloma (MM), and other hematologic diseases. Additionally, it explores the potential of PMPs as diagnostic and prognostic biomarkers, emphasizing their significance in understanding the pathogenesis and potential treatment of diverse hematological diseases.
Source: Blood and Genomics
Authors: Jiaqi Gu, Gengyin Wang
Language: English
Topic: Blood groups and transfusion
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4412403177