Work

Chemokine gradients spare graft endothelium from CD8+ T cell–mediated injury during allograft rejection

Year: 2025

Type: article

Abstract: T cell-mediated rejection (TCMR) develops after alloantigen-primed T cells migrate into an allograft to cause tissue damage. In contrast to antibody-mediated rejection, which creates lesions in the graft vasculature, injury to the graft vasculature is often limited during TCMR. In this issue of the JCI, Barba et al. investigated the mechanism by which the endothelium is spared from harm caused by graft-infiltrating CD8+ T cells. Endothelial cell protection was due to cell-extrinsic chemokine variations in the environment, rather than cell-intrinsic differences between endothelial and interstitial cells. The CXCL12 gradient in particular facilitated CD8+ T cell movement through the endothelial layer into the graft parenchyma. These findings suggest that targeting the CXCL12 pathway may prevent or alleviate TCMR.

Source: Journal of Clinical Investigation

DOI: 10.1172/jci193454

Authors: Scott M. Krummey, Jonathan S. Bromberg

Institutions: Johns Hopkins University, Johns Hopkins Medicine, University of Maryland, Baltimore

Language: English

Topic: Chemokine receptors and signaling

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $5,200