The relaxant effect of the extract of Crocus sativus petal on Wistar rats airway smooth muscle and its possible mechanisms.
Year: 2025
Type: article
Abstract: Objective: petal extract on tracheal smooth muscle (TSM) was assessed. Materials and Methods: petal extract (0.1, 0.2, 0.4 and 0.8 mg/ml), theophylline (0.2, 0.4, 0.6 and 0.8 mM) or 1 mL normal saline were tested. In non-incubated TSM and in TSM groups incubated with diltiazem, chlorpheniramine, propranolol, glibenclamide, atropine and indomethacin, the relaxant effects of the extract were evaluated. Results: petal extract in TSM incubated with chlorpheniramine and indomethacin, were significantly reduced compared to non-incubated tissues (p<0.05 to p<0.001). Conclusion: extract on TSM and suggest that inhibition of cyclooxygenase pathway and histamine receptors contribute to the extract relaxant effect of the extract.
Source: PubMed
Authors: Sepide Behrouz, Arghavan Memarzia, Mohammad Hossein Eshaghi Ghalibaf, Amir Hossein Yazdi, Mohammad Hossein Boskabady
Institution: Mashhad University of Medical Sciences
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4412424460