Work

Exploring the immune-boosting and hepatoprotective potential of Allium jesdianum against cyclophosphamide-induced toxicity in mice: A promising approach for immunomodulation.

Year: 2025

Type: article

Abstract: Objective: on CTX-induced toxicity in Nordic Medical Research Institute (NMRI) mice. Materials and Methods: liver biochemical test, serum antibody titer hemagglutination (HA), delayed-type hypersensitivity reaction (DTHR), lymphocyte proliferation, cytokine production, and spleen and liver histopathological features were assessed. Results: AJE effectively restored various parameters in immunosuppressed mice, including body and organ weight, WBC counts, liver biochemical markers, HA, DTHR, lymphocyte proliferation ability, and cytokine production. Notably, AJE significantly stimulated lymphocyte proliferation, enhanced both cellular and humoral immunity, restored the levels of interferon (IFN)-γ and interleukin (IL)-4, and reversed the splenic white pulp atrophy in the immunosuppressed mice. Conclusion: Analyses have shown that AJE exerts protective effects on the immune system of CTX-treated animals by boosting both cellular and humoral immunity, with no observed hepatoxicity.

Source: PubMed

DOI: 10.22038/ajp.2024.25258

Authors: Alireza Rezaei, Bahareh Sadat Yousefsani, Ameneh Omidi, Kobra Shirani

Institutions: Tarbiat Modares University, Iran University of Medical Sciences

Language: English

Topic: Garlic and Onion Studies

Subfield: Plant Science

Field: Agricultural and Biological Sciences

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: Tarbiat Modares University