Methanolic extract of Justicia secunda ameliorates the cyclophosphamide-induced hepatic and renal failures in rats.
Year: 2025
Type: article
Abstract: Objective: against cyclophosphamide-instigated hepatic and renal toxicities in rats and analyzed the bioactive constituents of the extract using gas chromatography mass spectrophotometry (GC-MS). Materials and Methods: Twenty male albino Wistar rats were assigned into four groups of five rats each: Group 1 received rat feeds and tap water for 14 days. Group 2 received rat feeds and water for 14 days and cyclophosphamide (CPH, 100 mg/kg.BW) on day 15. Group 3 received rat feeds and 200 mg/kg.BW of the extract for 14 days and CPH on day 15 while Group 4 received rat feeds and 400 mg/kg.BW of the extract for 14 days and CPH on day 15. Results: extract and acute toxicity study (using mice to determine the safety profile of the extract) showed the safety of the usage of the plant at 200 and 400 mg/kg doses. Conclusion: has protective effects against CPH-induced hepatic and renal toxicities which could be attributed to its bioactive compounds.
Source: PubMed
Language: English
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4412424790