Work

Associations between squalene epoxidase gene polymorphisms and obesity.

Year: 2025

Type: article

Abstract: Background: Among the known control points of cholesterol synthesis, squalene epoxidase (SQLE) is considered a key factor influencing cholesterol metabolism. Methods: A total of 1,045 consecutive participants were divided into an obese group and a control group. Blood biochemical markers were measured, and deoxyribonucleic acid (DNA) was extracted from all participants. Statistical analyses were conducted to assess the associations between SQLE gene single nucleotide polymorphisms (SNPs) and obesity. Results: . AA + AG) between the two groups. Conclusions: This study indicates a correlation between the SQLE gene polymorphisms rs10104486 and rs2288312 and obesity in a young population. Participants carrying the C allele of rs10104486 were more likely to develop obesity than those carrying the A allele, with the CC genotype identified as a predisposing factor.

Source: PubMed

DOI: 10.7717/peerj.19635

Authors: Jia-Qing Yu, Feng-Xia Wang, Shuai Liu, Bing Zhu, Yi-Tong Ma

Institution: First Affiliated Hospital of Xinjiang Medical University

Language: English

Topic: Genetic Associations and Epidemiology

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W4412424825

FWCI:

Cites: 22

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Related to: 10