Methanol leaf extract of Azadirachta indica mitigates isoproterenol-induced myocardial infarction through the modulation of oxidative stress, and PPARα and BCL2 signaling in rats.
Year: 2025
Type: article
Abstract: Objective: 's potential on the modulation of blood pressure parameters, antioxidant defense status, as well as immunohistochemical expressions of Peroxisome proliferator-activated receptor α (PPARα) and Bcl-2 (B-cell lymphoma 2) in rats exposed to isoproterenol was the objective of this study. Materials and Methods: ) of the Wistar strain were used, with myocardial infarction induced by intraperitoneal administration of isoproterenol (ISO) for two consecutive days. Cardiac and renal biomarkers of oxidative stress, blood pressure parameters, electrocardiography, and immunohistochemical staining of PPARα and BCL2 were performed. Results: improved antioxidant status, lowered free radical generation, mitigated serum myeloperoxidase and xanthine oxidase activities, respectively. Conclusion: suggest a positive modulatory role for the medicinal plant in isoproterenol-induced myocardial infarction.
Source: PubMed
Authors: Amirah Folashade Yusuf, Temitayo Olabisi Ajibade, Oluwaseun Olarenwaju Esan, Racheal Ebunoluwa Asenuga, Moyinoluwa Onoja, Matthew Obot Akpan, Joseph Ayotunde Badejo, Temidayo Olutayo Omobowale, Ademola Adetokunbo Oyagbemi, Adeolu Alex Adedapo, Oluwafemi Omoniyi Oguntibeju, Momoh Audu Yakubu
Language: English
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4412424874