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Chronic sleep deprivation is associated with delayed puberty onset in rats, activation of proinflammatory cytokines and gut dysbiosis.

Year: 2025

Type: article

Abstract: an increase in the expression levels of proinflammatory cytokines and altering the gut microbiome composition, indicating proinflammatory cytokines and gut microbiome play an important role in pubertal timing change. These findings may guide the future studies to intervene sleep deprivation-related delays in the onset of puberty.

Source: PubMed

DOI: 10.7717/peerj.19668

Authors: Shirley Priscilla Gunawan, Shih-Yi Huang, Jhih-Wei Hsu, Chia-Yuan Lin, Nam Nhat Nguyen, Te-Hsuan Tung, Shu-Ling Liang, Gilbert Aaron Lee, Chien-Tien Su, Yang Ching Chen

Institutions: Taipei Medical University, National Taiwan Ocean University, Chang Gung University, Taipei Medical University Hospital, Wan Fang Hospital

Language: English

Topic: Hypothalamic control of reproductive hormones

Subfield: Reproductive Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W4412424915

FWCI:

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