Work

Author response: A mathematical model for ketosis-prone diabetes suggests the existence of multiple pancreatic β-cell inactivation mechanisms

Year: 2025

Type: peer-review

Abstract: This theoretical study makes a useful contribution to our understanding of a subtype of type 2 diabetes -ketosis-prone diabetes mellitus (KPD) -with a potential impact on our broader understanding of diabetes and glucose regulation.The article presents an ordinary differential equationbased model for KPD that incorporates a number of distinct timescales -fast, slow, as well as intermediate, incorporating a key hypothesis of reversible beta cell deactivation.The presented evidence is solid and shows that observed clinical disease trajectories may be explained by a simple mathematical model in a particular parameter regime.

DOI: 10.7554/elife.100193.3.sa3

Authors: Sean A Ridout, Priyathama Vellanki, Ilya Nemenman

Institution: Emory University

Language: English

Topic: Pancreatic function and diabetes

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Funders: Emory University, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases

Award: Epigenetic Markers of Short- and Long- Term Near-Normoglycemia Remission in Patients with Ketosis-Prone Diabetes

OpenAlex ID: W4412427160

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