Personalized Meal Bolus Calculator for Type-1 Diabetes Accounting for Diurnal Effects
Year: 2025
Type: article
Abstract: Type 1 diabetes management requires compensating carbohydrate intake with bolus insulin matched to the meal size. Recent clinical studies revealed diurnal variations in insulin sensitivity (SI) in patients with type 1 diabetes, where the insulin resistance varies over the day. Diurnal variations in insulin sensitivity requires different bolus insulin dose for the same meal size depending on the time of the meal. Standard bolus calculators that use patient-specific parameters such as insulin-carb-ratio (CR) and correction factors (CF), however do not account for such diurnal variations. To address this gap, this paper proposes a fully data-driven safe and personalized bolus calculator that explicitly accounts for the diurnal variations. The proposed algorithm safely learns the optimum bolus needs tailored to each patient without the need for any patient-specific parameters such as carb-ratio, correction factor, insulin sensitivity etc., nor any historical clinical data. The proposed algorithm is tested and verified on the 10-adult cohort of the FDA-accepted UVA/Padova T1DM simulator.
Source: IFAC-PapersOnLine
Authors: Dinesh Krishnamoorthy, Francis J. Doyle
Institutions: Eindhoven University of Technology, Brown University
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4412437192