Morphometric Characteristics of the State of the Hemomicrocirculatory Bed of the Vascular Layer of the Eyeball at 6 Weeks of Diabetes Mellitus (experimental Investigation)
Year: 2025
Type: article
Abstract: According to the de昀椀ni琀椀on of the WHO expert group, diabetes mellitus, as a pandemic of the 21st century, occupies a leading place among the causes of disability of the able-bodied popula琀椀on of economically developed countries.In view of this, scien琀椀昀椀c research aimed at a thorough study of structural and ultrastructural changes in 琀椀ssues and organs in experimental models has gained priority.Laboratory rats of the Wistar line were chosen as the la琀琀er.The presented experimental study is aimed at 昀椀nding morphometric changes in the hemomicrocirculatory bed of the choroid of the eyeball of rats under condi琀椀ons of ar琀椀昀椀cially induced diabetes mellitus with streptozotocin in the period from 6 weeks from the onset of the disease.Considering the predominant lesion of the vascular link, we focused on the morphometric analysis of the angioarchitectonics of the eyeball, which is the basis for assessing the degree of pathological changes in its vasculariza琀椀on under condi琀椀ons of diabetes mellitus.The experiment proved that compensatory mechanisms are not able to reduce the scale of destruc琀椀on of the links of the hemomicrocirculatory bed of the choroid of the eyeball of white rats and the speci昀椀ed changes naturally pass into the stage of irreversible ones.In addi琀椀on, we noted a clear trend of growth in morphological changes in the structural elements of the choroid of the eye, the 昀椀ndings were characterized by direct correla琀椀ve rela琀椀onships with the dura琀椀on of the pathology, and, accordingly, the severity of the disease.A昀琀er 6 weeks of the experiment, we found that the destruc琀椀on of the choroid of the eyeball was at the stage of morphological decompensa琀椀on, and the capillaries of the membrane underwent signi昀椀cant destruc琀椀ve perturba琀椀ons, while the arterioles acquired a tortuous structure, with impaired patency and uneven lumen.No less signi昀椀cant were pathological devia琀椀ons of the capillary link of the ciliary processes, we observed frequent phenomena of capillary oblitera琀椀on, atrophic changes in the capillary component of the hemomicrocirculatory bed, and also iden琀椀昀椀ed fragments of individual capillaries completely deprived of their basic func琀椀ons. Key words: eyeball,
Institution: Danylo Halytsky Lviv National Medical University
Language: English
Subfield: Ophthalmology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4412454462