Clinical Case of the Clear Cell Variant of Papillary Thyroid Carcinoma
Year: 2025
Type: article
Study design: Case Report
Abstract: Contemporary medical literature indicates that metastases to the thyroid gland are relatively rare despite its rich vascular supply, accounting for approximately 1–3% of all malignant thyroid tumors. However, autopsy series studies demonstrate that metastases in the thyroid gland can be found in up to 24% of patients with advanced malignant disease.Objective. To examine a clinical case of a patient with papillary thyroid carcinoma.A clinical case was reviewed: Patient M., 75 years old, presented with a multinodular goiter.Results and Discussion: At the time of presentation, thyroid hormone levels were consistent with a euthyroid state. The patient complained of the presence of thyroid nodules and a sensation of discomfort. His medical history included previous surgical interventions: 25 years ago – left nephrectomy and splenectomy due to a renal neoplasm (discharge summaries not available); 10 years ago – prostatectomy and orchiectomy due to a malignant prostate tumor (no documentation provided). Laboratory parameters were within normal limits.Based on the medical history, physical examination, and ultrasound findings, a diagnosis of multinodular euthyroid goiter was established.A planned thyroidectomy was performed. No suspicion of malignancy was raised either prior to or during the surgical procedure.Histological Conclusion: Clear cell variant of papillary thyroid carcinoma.Oncologist's Conclusion: The treatment was carried out according to a radical protocol, and radioiodine therapy is not indicated for this patient. Replacement therapy with Euthyrox 100 mcg was prescribed.At follow-up visits, the patient's condition was satisfactory, with no complaints reported.Conclusion: Although metastases to the thyroid gland are rare, they should be considered in patients with a history of malignant tumors, particularly renal cell carcinoma.
Source: Bukovinian Medical Herald
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4412457472