Features of Ultrastructural Reorganization of Rat Kidneys Under Different Rehydration Methods After Severe General Dehydration
Year: 2025
Type: article
Abstract: The aim of the research to establish the features of ultrastructural reorganization of the kidneys of white rats when using various rehydration methods after severe general dehydration.Material and methods. The experiments were conducted on 24 white male rats, which were divided into five groups of 6 rats each: a control group, a group with simulated severe dehydration, and three groups that were rehydrated after severe dehydration by various agents. Ultrastructural examination of the kidneys was performed according to general rules.Results. The use of different methods of rehydration after dehydration in rats has a qualitatively identical, but quantitatively different effect on the recovery processes in the renal parenchyma. When drinking water was used for rehydration without restriction, after one day the changes that were detected in severe dehydration not only persisted, but also significantly deepened. When using saline without restriction, the dynamics of the functional state of the walls of hemocapillaries and epithelial cells in the proximal parts of the renal tubules were similar to those observed in the previous observation group. However, the intensity of the changes was lower, and the rate of their development was higher. The most effective was dosed correction with drinking water.Conclusions. 1. The use of different methods of rehydration after an anhydrous period in rats has a qualitatively identical, but quantitatively different effect on the structural organization of their kidneys. 2. When correcting with water without restriction on the first day, further worsening of circulatory disorders that were registered after dehydration was observed. After three days, reverse changes were noted, which continued in subsequent periods of observation. 3. The use of saline without restrictions is relatively more effective than the unlimited use of drinking water. However, the nature and dynamics of structural remodeling in the kidneys were similar, although less intense. 4. The most effective was the dosed use of drinking water.
Source: Bukovinian Medical Herald
Authors: Kh. Vakhnovska, I. Herasymiuk
Institution: I.Horbachevsky Ternopil National Medical University
Language: English
Topic: Acute Kidney Injury Research
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4412457605