Unveiling histotype-specific biomarkers in ovarian carcinoma using proteomics
Year: 2025
Type: article
Study design: Observational Study
Abstract: Epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy, yet clinical tools for diagnosis, prognosis, and treatment remain limited, and molecular profiling of histotypes is lacking. Here, we leverage proteomic data to further stratify four main EOC histotypes, borderline (BL) and benign (B) tumors, and identify candidate prognostic and diagnostic biomarkers. Using proteomic data from 300 patient samples, we identified differentially abundant proteins (DAPs) such as SNCG, S100A1, VWA2, AGR2, CTH, and SPINK1 and biomarker panels to stratify the tissues. Enrichment of biological processes profiled histotypes and involvement of DAPs. Survival analysis identified candidate biomarkers predicting overall- and disease-specific survival with histotype-specificity. Of these, GLYR1, RPL12, GDPGP1, and POLR2M were associated with favorable outcomes, while SDF4, PPP3CC, EIF2AK2, and STX6 were linked to unfavorable outcomes. Collectively, these findings provide histotype-specific attributes for known and EOC biomarkers that may serve as clinical tools for EOC diagnosis and treatment decisions.
Source: Molecular Therapy Oncology
Authors: Lucas Werner, Ella Ittner, Hugo Swenson, Elisabeth Werner Rönnerman, Claudia Mateoiu, Anikó Kovács, Pernilla Dahm-Kähler, Per Karlsson, Annika Thorsell, Elham Rekabdar, Parisa Esmaeili, Fredrik Levander, Eva Forssell-Aronsson, Axel Stenmark Tullberg, Ghassan Saed, Toshima Z. Parris, Khalil Helou
Language: English
Subfield: Reproductive Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,900
Funders: Cancerfonden, Stiftelsen Assar Gabrielssons Fond, Sahlgrenska Universitetssjukhuset, Göteborgs Universitet, Stiftelsen Konung Gustaf V:s Jubileumsfond, Stiftelsen Jubileumsklinikens Forskningsfond mot Cancer, Sahlgrenska University Hospitals Research Foundations, Health and Medical Care Committee of the Regional Executive Board, Region Västra Götaland
OpenAlex ID: W4412464827