Work

Isolated Gamma-Glutamyl Transferase Elevation in an Asymptomatic Adolescent: An Unusual Presentation of Focal Nodular Hyperplasia

Year: 2025

Type: article

Abstract: Incidental liver lesions (ILLs) in children are increasingly being identified due to the widespread use of imaging techniques. Focal nodular hyperplasia (FNH) is relatively rare in pediatric age, typically diagnosed based on characteristic imaging findings. We report the case of a 16-year-old asymptomatic female patient with persistent isolated elevation of gamma-glutamyl transferase (GGT), identified during routine evaluation. Further imaging, including abdominal ultrasound and magnetic resonance imaging with hepatocyte-specific contrast agent, revealed an ILL consistent with FNH, despite the absence of a classical central scar. The adolescent remained asymptomatic, and conservative follow-up was decided. This case highlights the diagnostic relevance of isolated GGT elevation as a potential indicator of FNH.

Source: Cureus

DOI: 10.7759/cureus.88050

Authors: Manuel Lima Ferreira, Teresa Cachada Baptista, Diana Alba, Ana Reis

Institution: Unidade Local de Saúde do Tâmega e Sousa

Language: English

Topic: Pediatric Hepatobiliary Diseases and Treatments

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4412467788