Work

Microscopic colitis in patients with diarrhea predominant irritable bowel syndrome

Year: 2025

Type: article

Abstract: Background and aim Functional bowel disorders, such as irritable bowel syndrome accompanied by diarrhea (IBS-D), present symptoms similar to microscopic colitis (MC), which include recurrent watery diarrhea and abdominal discomfort. This study aimed to find whether IBS-D patients have MC. Patients and methods The study involved 100 IBS-D patients based on Rome IV criteria. Participants underwent medical history assessment, clinical examination, and colonoscopy with biopsy and histological examination. Results The mean duration of diarrhea whether continuous or intermittent is 10.34±2.26. Histological examination of biopsy in patients with normal colonoscopy revealed that MC is present in 10% of the patients, and lymphoid hyperplasia and eosinophilic colitis constitute 4% of the patients for each one. Normal histological findings were found in 50% of IBS-D patients. MC patients were older and most of them were females when compared with the other IBS-D patients. Conclusion MC is a relatively common condition, particularly in older adults, and can be easily mistaken for IBS-D. Accurate diagnosis requires histopathological examination of colonoscopic biopsies from normal-appearing mucosa.

Source: Al-Azhar Assiut Medical Journal

DOI: 10.4103/azmj.azmj_17_25

Authors: Asem G.Y. Mohammed, Khaled A. Eid, Ahmed Q. Mohammed

Institution: Al-Azhar University

Language: English

Topic: Microscopic Colitis

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $250