Work

Construction of helicates based on six-coordinated silicon centres

Year: 2025

Type: article

Abstract: A class of triple-stranded helicates based on six-coordinate silicon centres has been constructed through self-assembly of achiral catechol ligands, as confirmed by single-crystal X-ray diffraction. These architectures demonstrate stability across physiological environments at pH = 3-12. Ligand rigidity dictates chiral configurations: rigid scaffolds form ΛΛ/ΔΔ racemic helicates, while flexible linkers enable dynamic equilibration with ΛΔ mesostates, observable by NMR. Host-guest interactions drive mesocate to helicate conversion, imparting cage-like guest recognition behavior. The helicates combine the biocompatibility of silicon with ligand-controlled chirality switching, offering potential for biomimetic applications.

Source: Chemical Science

DOI: 10.1039/d5sc03271g

Authors: Yu-Tao Guan, Heng Ji, Ju Yang, Sai-Sai Yu, Ming Liu

Institution: Zhejiang University

Language: English

Topic: Supramolecular Chemistry and Complexes

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: diamond

Funders: National Natural Science Foundation of China, Major Research Plan, Science and Technology Department of Zhejiang Province, Zhejiang Provincial Outstanding Youth Science Foundation

Awards: G1504493291, G2136601695, G691308719, G7858221522