Year: 2025
Type: article
Abstract: Background Post-surgical adhesions, i.e. , scar tissue inadvertently interlinking organs in the abdomen, is a common complication after surgery that can lead to infertility, small bowel obstruction and difficulties in subsequent surgeries. We explored an autologous method for preventing adhesions. Methods An autologous blood-derived patch, purely made from the patient's own blood, was tested in a porcine model. We performed laparotomies, damaged the uterine horns, positioned and fixed them in close proximity to a denuded area on the abdominal wall. One uterine horn was protected with a patch ( n = 11), the other acted as an untreated control. Four weeks after the surgery, adhesions were assessed macroscopically and microscopically. Results Uterine horns treated with a patch had significantly fewer and less severe adhesions. Furthermore, less inflammation and less intramural and peritoneal fibrosis was found in the patch-treated uterine horns. Conclusions We conclude that treatment with the blood-derived patch has potential for preventing post-surgical adhesions.
Source: Heliyon
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,270
OpenAlex ID: W4412470728